Stem Cell Theory of Aging Information
The stem cell theory of aging is a new theory which was recently formulated by several scientists and which postulates that the aging process is the result of the inability of various types of stem cells to continue to replenish the tissues of an organism with functional differentiated cells capable of maintaining that tissue (or organ) original function. Some of the proponents of this theory have been Norman E. Sharpless, Ronald A. DePinho, Huber Warner, Alessandro Testori and others. Dr Warner came to this conclusion after analyzing human case of Hutchinson's Guilford Syndrome and mouse models of accelerated aging.
References
- Sharpless N.E., DePinho, R. A. Telomeres, stem cells, senescence, and cancer. J. Clin. Invest. 113:160–168 (2004). doi:10.1172/JCI200420761.
- Chang, S., Khoo, C.M., Naylor, M.L., Maser, R.S., and DePinho, R.A. 2003. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev. 17:88–100.
- Metcalfe, J.A., et al. 1996. Accelerated telomere shortening in ataxia telangiectasia. Nat. Genet. 13:350–353.
- Hastie, N.D., et al. 1990. Telomere reduction in human colorectal carcinoma and with ageing. Nature. 346:866–868.
- Allsopp, R.C., et al. 1992. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 89:10114–10118.
- Frenck, R.W., Jr., Blackburn, E.H., and Shannon, K.M. 1998. The rate of telomere sequence loss in human leukocytes varies with age. Proc. Natl. Acad. Sci. U. S. A. 95:5607–5610.
- Liu, Y., Sanoff, H., Cho, H., Burd, C., Torrice, C., Ibrahim, J., Thomas, N., & Sharpless, N. (2009). Expression of p16INK4a in peripheral blood T-cells is a biomarker of human aging Aging Cell DOI: 10.1111/j.1474-9726.2009.00489.x
- Warner HR. 2006 Kent award lecture: is cell death and replacement a factor in aging? J Gerontol A Biol Sci Med Sci. 2007 Nov;62(11):1228-32.
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