Ronald a. Depinho Information
Ronald A. DePinho, M.D. is a Portuguese-American Cancer Biologist, currently a Professor at the Dana Farber Cancer Institute and Harvard Medical School. He is best known for his work on Telomeres in cancer and aging, for the discovery of which, the 2009 Nobel prize in Medicine was awarded to Ron DePinho's close collaborator, Carol Greider. His seminal contribution include the generation of the first telomerase knockout mouse, in collaboration with Carol Greider,[1] and their characterization with respect to lifespan, cancer predisposition and the interaction of short telomeres with p53.[2][3][4] His recent work on telomerase re-activation, showing that it is possible to reverse key dysfunctional telomere-related phenotypes in aged mice (including reversing brain atrophy, reversing sterility), has generated considerable media interest, because of its potential importance for reversing the phenotypes of aging.[5][6] He has also worked on c-myc, ink/arf, p53 and Foxo transcription factors. His more recent work concerns the oncogenomics of glioblastoma and pancreatic cancer.
Life and career
Dr. DePinho received his MD with distinction from Albert Einstein Medical College in 1981. He later completed his research training at Columbia Presbyterian Hospital, and in 1998, joined Dana-Farber Cancer Institute, where his laboratory has dissected the roles of Myc, Rb, p53, and telomerase in cancer and senescence.[7] On May 11, 2011 it was announced that he was the sole finalist to succeed John Mendelsohn as president of the University of Texas MD Anderson Cancer Center. [8]
Awards and honors
- Albert Szent-Gyrgyi Prize for Progress in Cancer Research (2009)
- Helsinki Medal (2007)
- Albert Einstein College of Medicine Distinguished Alumnus Award (2004)
- American Cancer Society Edith A. Pistorino Research Professorship (2004)
- Member, Institute of Medicine of the National Academies (2004)
- AACR-G.H.A. Clowes Memorial Award (2003)
- American Society for Clinical Investigation Award (2002)
- American Society for Clinical Investigation Award (2000)
References
- ^ Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.Cell. 1997 Oct 3;91(1):25-34
- ^ Essential role of mouse telomerase in highly proliferative organs.Nature. 1998 Apr 9;392(6676):569-74
- ^ Longevity, stress response, and cancer in aging telomerase-deficient mice.Cell. 1999 Mar 5;96(5):701-12.
- ^ p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis.Cell. 1999 May 14;97(4):527-38.
- ^ Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, Horner JW, Maratos-Flier E, Depinho RA. Nature. 2010 Nov 28.
- ^ http://online.wsj.com/article/SB10001424052748703785704575642964209242180.html
- ^ http://physicians.dana-farber.org/directory/profile.asp?dbase=main&set&display=Y&nxtfmt=r&gs=r&picture_id=0000067&lookup=Y&pict_id=0000067
- ^ http://www.utsystem.edu/news/2011/BOR-UTMDACC-president-finalist-05-11-11.html
Lab web page: http://research4.dfci.harvard.edu/DePinho/DePinho_Lab/Home.html
Media appearance: http://www.colbertnation.com/the-colbert-report-videos/370184/january-06-2011/ronald-depinho
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Categories: Harvard Medical School faculty | American physicians | Living people
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